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Mice given an experimental gene treatment do not get fats, without reference to caloric consumption / Boing Boing

Researchers at Flinders University knocked out a gene referred to as RCAN1 in mice, hypothesizing that this is able to increase “non-shivering thermogenesis,” which “expends calories as heat rather than storing them as fat” — the mice have been fed a high-calorie vitamin and didn’t gain weight.

In specific, the changed mice didn’t retailer fats round their middles — a phenomenon related to many health dangers, including cardiac issues — and their resting muscle tissue burned extra energy.

I wrote this into my 2009 novel Makers, and described a era of previously overweight individuals who at first thrilled in gorging on huge foods, then discovered that they have been at risk of going broke paying for all of the energy they had to continue to exist.

The find out about’s authors indicate that there’s a time and position for RCAN1’s function in fighting energy from being burned: specifically, again when meals used to be scarce and energy weren’t so readily to be had. In the fashionable global of “caloric abundance”, alternatively, an excessive amount of fats is being saved and genuine health issues are resulting consequently. The researchers recommend that “These adaptive avenues of energy expenditure [such as RCAN1] may now contribute to the growing epidemic of obesity.”

“We checked out quite a lot of other diets with more than a few time spans from 8 weeks as much as six months,” stated Damien, “and in each and every case we noticed health enhancements within the absence of the RCAN1 gene.

“Mice on a high-fat diet that lacked this gene gained no weight.”

A New Drug Could Let Us Eat Anything Without Gaining Weight [Gavin Butler/Vice]

Regulator of Calcineurin 1 is helping coordinate complete‐body metabolism and thermogenesis [David Rotter, Heshan Peiris, D Bennett Grinsfelder, Alyce M Martin, Jana Burchfield, Valentina Parra, Christi Hull, Cyndi R Morales, Claire F Jessup, Dusan Matusica, Brian W Parks, Aldons J Lusis, Ngoc Uyen Nhi Nguyen, Misook Oh, Israel Iyoke, Tanvi Jakkampudi, D Randy McMillan, Hesham A Sadek, Matthew J Watt, Rana K Gupta, Melanie A Pritchard Damien J Keating and Beverly A Rothermel/Embo Reports] (Sci-Hub reflect)

Gene that permits you to consume up to you wish to have holds promise against weight problems [Flinders University/Science Daily]


Cory Doctorow

I write books. My newest are: a YA graphic novel referred to as In Real Life (with Jen Wang); a nonfiction guide concerning the arts and the Internet referred to as Information Doesn’t Want to Be Free: Laws for the Internet Age (with introductions by means of Neil Gaiman and Amanda Palmer) and a YA science fiction novel referred to as Homeland (it is the sequel to Little Brother). I discuss in all places and I tweet and tumble, too.


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